diff --git a/openssl-sys/src/lib.rs b/openssl-sys/src/lib.rs
index 300ed056ef26e6a30bc26f8f370896223708ee10..482317fff883326c75c7545152c7599224750ac3 100644
--- a/openssl-sys/src/lib.rs
+++ b/openssl-sys/src/lib.rs
@@ -587,6 +587,7 @@ extern {
     pub fn SSL_get_ex_data_X509_STORE_CTX_idx() -> c_int;
     pub fn SSL_get_SSL_CTX(ssl: *const SSL) -> *mut SSL_CTX;
     pub fn SSL_set_SSL_CTX(ssl: *mut SSL, ctx: *mut SSL_CTX) -> *mut SSL_CTX;
+    #[cfg(not(osslconf = "OPENSSL_NO_COMP"))]
     pub fn SSL_get_current_compression(ssl: *mut SSL) -> *const COMP_METHOD;
     pub fn SSL_get_peer_certificate(ssl: *const SSL) -> *mut X509;
     pub fn SSL_get_ssl_method(ssl: *mut SSL) -> *const SSL_METHOD;
@@ -603,6 +604,7 @@ extern {
     #[cfg(not(ossl101))]
     pub fn SSL_get0_param(ssl: *mut ::SSL) -> *mut X509_VERIFY_PARAM;
 
+    #[cfg(not(osslconf = "OPENSSL_NO_COMP"))]
     pub fn SSL_COMP_get_name(comp: *const COMP_METHOD) -> *const c_char;
 
     pub fn SSL_CIPHER_get_name(cipher: *const SSL_CIPHER) -> *const c_char;
diff --git a/openssl/build.rs b/openssl/build.rs
index 15d4b4db8f6458808da16687df0df582b1082d4c..dd83215062242fb7db9ad5fecfb7290688289f54 100644
--- a/openssl/build.rs
+++ b/openssl/build.rs
@@ -12,4 +12,9 @@ fn main() {
     if env::var("DEP_OPENSSL_IS_110").is_ok() {
         println!("cargo:rustc-cfg=ossl110");
     }
+    if let Ok(vars) = env::var("DEP_OPENSSL_OSSLCONF") {
+        for var in vars.split(",") {
+            println!("cargo:rustc-cfg=osslconf=\"{}\"", var);
+        }
+    }
 }
diff --git a/openssl/src/ssl/mod.rs b/openssl/src/ssl/mod.rs
index b042d81e73eff0a61f9ea2f449af54953320b27b..076ac40017d9e631028a83f4f0747438812cab70 100644
--- a/openssl/src/ssl/mod.rs
+++ b/openssl/src/ssl/mod.rs
@@ -952,6 +952,11 @@ impl<'a> SslRef<'a> {
     /// The result will be either None, indicating no compression is in use, or
     /// a string with the compression name.
     pub fn compression(&self) -> Option<String> {
+        self._compression()
+    }
+
+    #[cfg(not(osslconf = "OPENSSL_NO_COMP"))]
+    fn _compression(&self) -> Option<String> {
         let ptr = unsafe { ffi::SSL_get_current_compression(self.as_ptr()) };
         if ptr == ptr::null() {
             return None;
@@ -965,6 +970,11 @@ impl<'a> SslRef<'a> {
         Some(s)
     }
 
+    #[cfg(osslconf = "OPENSSL_NO_COMP")]
+    fn _compression(&self) -> Option<String> {
+        None
+    }
+
     /// Returns the server's name for the current connection
     pub fn servername(&self) -> Option<String> {
         let name = unsafe { ffi::SSL_get_servername(self.as_ptr(), ffi::TLSEXT_NAMETYPE_host_name) };