diff --git a/openssl-sys/build/expando.c b/openssl-sys/build/expando.c
index 11fb04db0c7c6806749a98d4dd4d60c14c07e537..54681a0b95f0add09156a95cd9a4f1817d1174e0 100644
--- a/openssl-sys/build/expando.c
+++ b/openssl-sys/build/expando.c
@@ -79,6 +79,10 @@ RUST_CONF_OPENSSL_NO_OCSP
 RUST_CONF_OPENSSL_NO_PSK
 #endif
 
+#ifdef OPENSSL_NO_RC4
+RUST_CONF_OPENSSL_NO_RC4
+#endif
+
 #ifdef OPENSSL_NO_RFC3779
 RUST_CONF_OPENSSL_NO_RFC3779
 #endif
diff --git a/openssl-sys/src/handwritten/evp.rs b/openssl-sys/src/handwritten/evp.rs
index 050d2c88bb43e00e8fe03d349c1977971a66cb30..db018e9a4288990e5cdc857733a4e3d9498723af 100644
--- a/openssl-sys/src/handwritten/evp.rs
+++ b/openssl-sys/src/handwritten/evp.rs
@@ -311,6 +311,7 @@ extern "C" {
     pub fn EVP_des_ede3_cbc() -> *const EVP_CIPHER;
     pub fn EVP_des_ede3_cfb64() -> *const EVP_CIPHER;
     pub fn EVP_des_cbc() -> *const EVP_CIPHER;
+    #[cfg(not(osslconf = "OPENSSL_NO_RC4"))]
     pub fn EVP_rc4() -> *const EVP_CIPHER;
     pub fn EVP_bf_ecb() -> *const EVP_CIPHER;
     pub fn EVP_bf_cbc() -> *const EVP_CIPHER;
diff --git a/openssl/src/cipher.rs b/openssl/src/cipher.rs
index aeedf459aaaf08abf1e109ab4610c995b9be5635..87f7660cde2853f364c0655be91eed118bd463aa 100644
--- a/openssl/src/cipher.rs
+++ b/openssl/src/cipher.rs
@@ -324,6 +324,7 @@ impl Cipher {
         unsafe { CipherRef::from_ptr(ffi::EVP_des_ede3_cfb64() as *mut _) }
     }
 
+    #[cfg(not(osslconf = "OPENSSL_NO_RC4"))]
     pub fn rc4() -> &'static CipherRef {
         unsafe { CipherRef::from_ptr(ffi::EVP_rc4() as *mut _) }
     }
diff --git a/openssl/src/symm.rs b/openssl/src/symm.rs
index 911a7ab2e7530ac59f3ca25f776a9402a095733f..611080805f91ea378f08cd6d8ee337ca8526142a 100644
--- a/openssl/src/symm.rs
+++ b/openssl/src/symm.rs
@@ -283,6 +283,7 @@ impl Cipher {
         unsafe { Cipher(ffi::EVP_des_ede3_cfb64()) }
     }
 
+    #[cfg(not(osslconf = "OPENSSL_NO_RC4"))]
     pub fn rc4() -> Cipher {
         unsafe { Cipher(ffi::EVP_rc4()) }
     }